Drug Discovery, Enzymology, Biochemistry, Biophysics at Capienda Biotech

Dr. Bernard is a leading research biochemist and enzymologist with 16 years of experience in pharma/biotech industry. His areas of expertise include nucleotide metabolism, nucleic acids and enzymology. In large pharma (Pfizer, Bayer) and startups, Dr. Bernard’s research involved drug discovery and mechanism of action for biopharmaceuticals and small molecules in oncology, immunology and hematology. At the Pfizer Oligonucleotide Therapeutics Unit, he invented an enzymatic platform to optimize therapeutic RNA interference molecules and provide mechanistic insight. Bringing his RNAi expertise to Harvard Medical School, he discovered that HIV encodes novel microRNAs that stimulate a pro-inflammatory response through an unconventional mechanism. At Targeted Molecules Corp., Dr. Bernard initiated the program for anti-inflammatory Vatelizumab taking the program from proposal and drug discovery through humanization leading to IND. Vatelizumab completed Phase II clinical trials (Sanofi/Glenmark, $613M deal).

In biotechnology, he co-founded Capienda Biotech to develop an advanced bioanalytical platform provide high-throughput experimental results for Medicinal Chemists to accelerate Drug Discovery for the Pharma Industry.  Previously, he led enzymology research at the startup Omniome to produce an enzymatic platform for label-free Next-Gen Sequencing, and at SmithKline Beckman/Beckman Instruments he produced 11 marketed IVD products.

He earned degrees from the University of California, Los Angeles (B.S. Biochemistry) and Oregon State University (Ph.D. Biochemistry and Biophysics) followed by post-doctoral research at University of Texas Medical School (Medical Genetics) and Harvard Medical School (HIV and host defense). He has 10 peer-reviewed publications, 6 Patents issued/pending and prior experience at 2 startups.  


Mark Bernard 64sc

Mark Bernard


Attend SDEE Events Donate | Sponsor SDEE Become a Member

Connect with SDEE

Sign Up for SDEE Newsletter


SDEE PLATINUM SPONSORS

Morrison Foerster Alexandria

Struthers Family
Trust

SDEE GOLD SPONSORS

BioMed Realty

Ted Jacobs
Executive Managing Director
Global Life Sciences Practices Group

Brex logo

SDEE SILVER SPONSORS

Takeda San Diego Union Bank JP Morgan logo

SDEE BRONZE SPONSORS

Duane Morris MaxCyte Wagenknecht Barney and Barney Longfellow

SDEE is a nonprofit 501(c)(3) organization founded by local San Diego entrepreneurs
in order to provide a voice for the early stage start-up, to support new entrepreneurs and their companies,
and to sponsor networking and educational events
to help develop the skills necessary to bring funding, business, and jobs to the San Diego area.

© 2015 San Diego Entrepreneurs Exchange. All Rights Reserved